Drug Discovery: Here Comes the Worm

Drug discovery: here comes the worm.

Identification of bioactive molecules and their targets impedes the process of drug development. In a recent paper, a genetically tractable organism, the Caenorhabditis elegans worm, is shown to be a viable screening system in which the drug target and the pathway it activates can be readily identified.

Here Comes the Sun

The effect of cancer cachexia on the oxidative metabolism of lipids has been studied in mice transplanted either with the MAC16 adenocarcinoma, which induces profound loss of host body weight and depletion of lipid stores, or the MAC13 adenocarcinoma, which is of the same histological type, but which grows without an effect on host body weight or lipid stores. While oxidation of D-[U-'4C]glucos...

Here comes the cord

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Hematopoietic stem cell transplantation has been established as a lifesaving therapy for leukemias or other hematopoietic malignancies since more than a half century ago [1]. Human leukocyte antigen (HLA)-matched sibling is the preferred donor for the better...

Here comes the sun.

Here Comes Hypercar!

Background: With the present study we introduce a novel and simple biomaterial able to induce regeneration of bone. We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets may initiate a series of biological processes that culminate in bone regeneration. Thus, we engineered CS-Platelet, a biomaterial based on the combination of Calcium Sulfate and ...